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Despite all the beneficial effects of IGF-I described up to now and the following ones reporting its role in aging-related pathologies as musculoskeletal, neurodegenerative, cardiovascular diseases, IGF-I has been paradoxically negatively related to lifespan[266, 267], probably due, at least in part, to its downstream molecule Akt and its interactions with FOXO, mTOR and SIRT-1, among others[268, 269]

Preclinical studies show accelerated tendon healing, enhanced collagen synthesis, and improved biomechanical outcomes in animal models

Ji et al., 2020)

Educating patients about the concept of exchange lists helps them understand how foods can be organized into groups with similar characteristics, such as calorie content and macronutrient composition