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Intercellular adhesion molecule 1 ( Icam1 ) mediates the adhesion and transmigration of leukocytes across the endothelium to promote inflammation in the vasculature

[5] On May 5, 2010 the Italian Medicines Agency (AIFA - Agenzia Italiana del Farmaco) became the first governmental health organization ever (even before the drug received approval in Europe) to authorize afamelanotide as a medicine for therapeutic treatment of Italian citizens to reduce painful photosensitivity stemming from the orphan disease erythropoietic protoporphyria (EPP)

Serious side effects are rare but require vigilance and prompt medical attention

Harach T, Marungruang N, Duthilleul N et al (2017) Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota