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Meanwhile, the ratio of GSR to GPX4 at the protein level was decreased in the A2ARi-treated group compared with the control group (Figure 3I), indicating that the GSSG accumulation upon A2ARi treatment is caused likely by an impaired capacity to recycle GSSG back to GSH

Glossary WAT white adipose tissue TAG triacylglyceride FA fatty acid DAG diacylglyceride MAG monoacylglyceride Lipolysis the hydrolysis of TAG to generate nonesterified fatty acids (FAs) and glycerol that are released into the vasculature for use by other organs as energy substrates HSL hormone-sensitive lipase ATGL adipose triglyceride lipase TGH triacylglyceride hydrolase MGL monoglyceride lipase PKA protein kinase A cAMP cyclic AMP PKB protein kinase B PTH parathyroid hormone VD 3 1,25(OH)2 vitamin D 3 LITERATURE CITED 1.Abramson EA, Arky RA