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The link of acetylcholine (Ach) releasing from the distal end of the vagal nerve and 7-nicotinic Ach receptor (7nAchR) in immune cells had the potential to suppress the production of pro-inflammatory cytokines, but not influence anti-inflammatory cytokines, such as IL-10 [46]

251 Impaired neurotrophic support In DPN, levels of neurotrophic factors are significantly reduced due to hyperglycemia-induced metabolic disturbances