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Changes in its activity are associated with the activation of redox signaling, which in turn regulates the cell death machinery [3]

[DOI] [PubMed] [Google Scholar] 87.Marchioro H.Z., Silva de Castro C.C., Fava V.M., Sakiyama P.H., Dellatorre G., Miot H.A

doi:10.1016/j.ebiom.2025.105836 Compliance Statement This product is intended for laboratory research use only and is not approved for human or veterinary use.

In addition, as mentioned previously that MMP-2 was significantly increased in leiomyoma cells, Curcumae rhizoma was also reported to inhibit the expression of MMP-2 which could also contribute to its use in the treatment of UF ( Curcumae rhizoma was also able to induce apoptosis by decreasing the level of BCL-2 and at the same time inhibit the phosphorylation of the AKT/NF-B pathway ( When both of these herbs are used together (known as CRSR, CR:SR = 1:1) in the treatment of UF, the uterine mass was found to be decreased significantly with a significantly lowered progesterone and estradiol level