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Description

The E167K variant enhances the interaction between TM6SF2 and the PNPLA3 variant I148M, which inhibits the function of PNPLA3 in mediating the transfer of polyunsaturated fatty acids (PUFAs) from TG to phosphatidylcholine, leading to increased accumulation of polyunsaturated TG in the liver and exacerbation of liver injury [271]

This study also eliminates ultrasonication and multi covalent coupling procedures

It also counteracts the detrimental effects of the polycyclic aromatic hydrocarbon benzo--pyrene on human sperm [145], and significantly improves the fertilization capacity in humans and animal models [146,147,148]