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To clearly illustrate the experimental basis for these findings, Table 1 summarizes key studies supporting the core pathways, including the experimental models used, the CKD stage or modeling approach, and the significant findings

Bioresponsive polyplexes-chemically programmed for nucleic acid delivery

ROS comprises both free and non-free radicals derived from oxygen atoms, including superoxide anion (O 2 - ), hydrogen peroxide (H 2 O 2 ), hydroxyl radicals (OH ), and singlet oxygen ( 1 O 2 ) [4]