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Meanwhile, the broader senolytic field has advanced dasatinib+quercetin has completed multiple human trials including Phase 2 in Nature Medicine (Farr 2024)

Additionally, the transcription factor FOXO1, a major regulator of metabolic reprogramming in NSCLC, plays crucial roles in glucose metabolism, lipid oxidation, and cellular stress responses

48 MiR-128-3p simultaneously inhibits the expression of AXIN1, SFRP2, and WIF1 to enhance the activity of the Wnt/-catenin signalling pathway, thus promoting non-small cell lung cancer (NSCLC) metastasis