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What Benzodiazepine Withdrawal Symptoms Can Feel Like How benzodiazepines affect the brain Benzodiazepines act primarily as positive allosteric modulators at gamma-aminobutyric acid type A (GABA-A) receptors, enhancing the inhibitory action of endogenous GABA and reducing neuronal excitability in the central nervous system

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Patches stick more successfully to thin-skinned spots with an abundance of blood supply, like the inner wrist, upper arm, lower back, or behind the ear, he says, while ineffective spots include the soles of your feet or areas where hair would prevent the patch from sticking properly