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Nuclear factor erythroid 2-related factor 2 plays a fundamental role in the response to oxidative stress and xenobiotic metabolism and detoxification, and the Nrf2 signaling pathway is intimately associated with development of atherosclerosis

Studied in fibroblast proliferation/migration, wound-closure and scratch assays, angiogenesis and vascular adaptation, oxidative stress and inflammation-linked pathways in laboratory models

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In particular, polar bear liver, a component of the Inuit diet, contains extraordinarily high levels of vitamin A (35,000 IU/g versus the RDA of 5000 IU), which can lead to acute hypervitaminosis A and death