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The popular claim that the effect fades after 4 to 6 weeks so you have to cycle is a widely repeated myth with no primary study behind it, and the mechanism actually argues against a classic tolerance effect

doi: 10.1002/jcla.23798 109

When exposed to high levels of NaCl, all the examined plants produced considerable amounts of H 2 O 2 , and CAT activity rose dramatically in response to the NaCl treatment (Nounjan et al., 2012)

Results: Meta-analysis showed a statistically significant effect of curcumin on depressive symptoms (SMD: 0.65, P = 0.01, 95% CI: 1.16 to 0.13, I 2 = 93%) and anxiety symptoms (SMD: 0.22, P = 0.01, 95% CI: 0.40 to 0.05, I 2 = 0%)