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Description

Staroverov, V

A role for ironsulfur clusters in DNA repair

Anti-TfR1 (136800), anti-iron sulfur cluster assembly scaffold protein (ISCU) (MA5-26595), anti-mitochondrial acyl carrier protein (mtACP) (PA5-30099), anti-GPX4 (MA5-32827), propidium iodide (PI) (11539226), anti-NDUFS1 (PA5-22309), Mitotracker Deep Red FM (M22426), anti-mouse Alexa Fluor 488 (MN1000), anti-rabbit Alexa Fluor 455 (437695), 4,6-diamino-2-phenylindole (DAPI) (D1306), bovine serum albumin (BSA) (BP9702), Hoechst 3342 (62249), and Bodipy 581/591 C11 (D3861) were purchased from Invitrogen/Molecular probes (Eugene, OR, USA)/ThermoFisher Scientific (Waltham, MA, USA)

28 Additionally, a 16-week trial of supplementation with GlyNAC (which boosts glutathione levels) in older adults improvedand in some cases reversedmultiple hallmarks of aging, including inflammation, mitochondrial dysfunction, and oxidative stress