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693 These findings suggest that FGF21 may be a new therapeutic target for SCI neurorehabilitation, and activation of FGF21 may provide a potential treatment for SCI

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These include 3-hydroxy-3-methylglutaryl-CoA reductase ( HMGCR ), mevalonate kinase ( MVK ), fatty acid desaturase 1 ( FADS1 ), and sterol-C5-desaturase ( SC5D ) involved in lipid metabolism, and others involved in the formation of actin filaments (palladin) and with actin binding activity ( CTNNAL1 )

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Consistently, low-dose intranasal administration of RNs has been investigated for neuroprotection in an EAE mouse model of MS

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