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After all, Steve Jobs once said that taking LSD is one of the two or three most important things I have done in life, and that Bill Gates would be a more open-minded guy if he had dropped acid from time to time. Austen Allred, CEO of Bloom Tech, warned about the corporate consequences of the popularization of ayahuasca among millionaire entrepreneurs

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The exploration of the possible mechanisms for relieving headaches has aided in the discovery of the protection and prevention of neuroinflammation in animal models (di Giacomo et al., 2019)

This process is intimately linked to ROS generation, as AGEs-RAGE interaction induces NADPH oxidase (NOX1, NOX4) expression, triggering sustained superoxide and H 2 O 2 production that further modifies ECM integrity (Yang et al., 2024