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78 On the flip side, insulin resistance single-nucleotide polymorphisms and lifestyles combined synergistically increased the risk of breast cancer in a gene-behavior, dose-dependent manner, suggesting lifestyle changes can prevent breast cancer in women who carry the risk genotype

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ROS can also cause an imbalance in mitochondrial metabolism, causing change in membrane permeability and halting the ATP production, which in turn cause cell cycle alterations, ultimately leading to the cancer appearance (Figure 2) [21]