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Glu, the primary excitatory neurotransmitter in the brain, also serves as a precursor for the inhibitory neurotransmitter GABA (86)

He CC, Klionsky DJ

These findings suggest that at least some phenomic changes of astrocytes may have causal effects on synaptic function, possibly contributing to disease phenotypes that may emerge in aging and AD (Endo et al., 2022)