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Furthermore, LA, an -6 PUFA, is positively correlated with albumin and hemoglobin levels in cachexia patients, suggesting potential nutritional support from increased dietary LA

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Mechanistically, these agents activate the Nrf2/ARE, NF-B, MAPK, PI3K/Akt/mTOR, and SIRT1/PGC-1 pathways, protect mitochondria and the bloodnerve barrier, and upregulate endogenous antioxidant enzymes

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