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It is important to search for safe and low-cost alternative therapies for CF and, in this context, natural compounds and, mainly, caffeic acid phenethyl ester (CAPE) appear as promising strategies to assist in the treatment of the disease

We found that 23 of 34 acivicin-induced genes and 2 of 5 acivicin-suppressed genes were, respectively, up- and down-regulated in long-lived mitochondrial mutants (Fig