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For example, studies have demonstrated that BMP4 upregulated by high expression of METTL3 and OCS3 and downregulated by low expression of FTO contributed to ectopic ossification of the posterior longitudinal ligament and ligamentum flavum [145, 146]

In this context, collaborative efforts are equally needed by researchers, industry stakeholders, and regulatory bodies to develop standardized protocols and guidelines to limit such environmental and regulatory hurdles

Ethical approval This article does not contain any studies with human participants or animals performed by any of the authors, except for those published previously and approved by respective ethic committees

The study was approved by the Local Ethics Committee at School of Medicine (University of Zagreb, Zagreb, Croatia) and experiments were assessed by observers unaware of the given treatment