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10.1021/acs.bioconjchem.4c00462 175 WangS.LiuY.SuM.WangY.WangW.WangW.et al (2024c)

Canadian Journal of Diabetes

This is not a true detoxification process as the dihydrodiol product can rearrange at neutral pH values to form a dialdehydic phenolate ion

Imidazolidinone (IKE), a derivative based on the improved structure of erastin, further improved the aqueous solubility and anticancer properties of the prototype, with three times the solubility of erastin and a 50-fold reduction in the LC50 for tumor cells [165, 166]