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doi: 10.4314/biokem.v16i2.32574 124 OlubiO.Felix-MinnaarJ

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One patient permanently discontinued study therapy because LVEF dropped from 70% at baseline to 24% after nine cycles and did not improve to more than 50% within 4 weeks of treatment interruption

We consistently obtained 9098% of SRY-box Transcription Factor 17 (SOX17) + and FOXA2 + definitive endoderm (DE) cells at day 4, 75% of cells expressing a posterior foregut (PFG) marker Hematopoietically Expressed Homeobox (HHEX) at day 6, 8090% pancreatic and duodenal homeobox 1 (PDX1) + and SRY-Box Transcription Factor 9 (SOX9) + pancreatic endoderm (PEN), 6880% pancreatic progenitors (PP) co-expressing PDX1 and NK6 Homeobox 1 (NKX6-1)-at day 12, 65% of Chromogranin-A (CHGA) + and PDX1 + endocrine progenitors (EP) and 3050% cells co-expressing C-peptide (C-PEP) and NKX6-1 (Fig