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In an in vivo study, curcumin failed to establish detectable plasma levels even at an oral dose of 180 mg 63

Overall, oral GABA intake appears to offer sleep benefits by enhancing relaxation and potentially alleviating sleep disturbances (Abdou et al., 2006)

The AhR, a crucial sensor of environmental signals, participates in the DNA damage process through multiple mechanisms upon activation: By directly upregulating the expression of metabolizing enzymes such as cytochrome P450s (CYP1A1, CYP1B1) and aldo-keto reductases (AKRs), AhR promotes the metabolic activation of procarcinogens like polycyclic aromatic hydrocarbons (PAHs) (Shen et al., 2005