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7), we emphasize that the ICV component served primarily as a preclinical proof-of-concept to validate direct CNS engagement for neural repair

doi: 10.1007/s00248-008-9457-9 6 DorokhovY

Reichard et al., 2007) (Figure 1)

Furthermore, the abnormal aggregation of -syn to form LB interferes with cellular autophagy and protein degradation pathways, representing a significant indicator of neuronal degeneration and cell death (Meredith et al., 2002)