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Since NNMT is expressed in adipose, hepatic, and gut tissues 50,51,52 , and these tissues heavily cross-talk with the gut microbiome 53,54,55 , NNMTi treatment or its resulting weight loss effects 8,9 may modulate the microbiome

Using both is redundant rather than synergistic and may cause NAD+ oversupply, which preliminary research suggests could impair SIRT1 regulation

Because it restores physiologic GH pulsatility rather than delivering exogenous GH, Tesamorelin produces a more favorable side-effect profile than direct GH administration in research settings