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In addition, the energy required to break the Cu 2+ /imidazolyl coordination bond is not the lowest in comparison to Cu 2+ /carboxyl and Cu 2+ /amino coordination, leading to a negative impact on the catalytic activity also 28,29

But, this could also be explained by Simpson's Paradox: The national aggregate death count driven down by more substantial decreases in larger population states, while some states are going up