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The association between MMP-9, p38 kinase and MCLK is likely mediated by the pro-inflammatory transcription factor NF-kB, as silencing of the p38 kinase prevented MMP-9 from activating NF-kB p65 and increasing MLCK expression [91]

Kanayama G, DeLuca J, Meehan WP, et al

Though functional roles of the VGF peptides detected here remain to be established, consistent changes in VGF abundance across proteoforms between diagnostic classes in the present study, as well as previous literature, suggest clear roles of VGF peptides in cognitive functioning 15