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Metabolic disorders directly affect age-related functional disability in the heart because they can cause a shortage of energy supply, leading to cardiac senescence [4, 23]

It was proposed that high GSTU activity, due to a high endogenous level of expression, was at the center of the observed differential sensitivity to herbicides between cereals (e.g., maize, wheat, and rice) and weeds (Cummins et al., 2011)

A clear decrease in the HBV RNA level was observed in cells transfected with Flag-HBc, and this decrease was abolished by BafA1 (Fig

In favor of this hypothesis, it has been observed that suramine (a drug used to treat trypanosome infection and also, recently, to treat solid tumors), which has the same mechanism of action as sorafenib, inhibiting RAF kinase, also induces keratoacanthomas and SCC.31 In addition, vemurafenib, a selective RAF inhibitor employed in patients with metastatic melanoma carrying the BRAF V600E mutation, has also been found to increase the incidence of SCC and keratoacanthoma .29,32 It has been shown that cells of SCCs from patients treated with RAF inhibitors presented a different profile of mutations from typical SCCs