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The compound's anti-inflammatory properties contribute to joint recovery by reducing synovial inflammation, a primary driver of pain and restricted movement

Cagrilintide and semaglutide work through different mechanisms and have different dosing schedules: Cagrilintide: Amylin receptor agonist Escalation: 0.6 mg 1.2 mg 2.4 mg weekly Three-step titration over 8 weeks Semaglutide: GLP-1 receptor agonist Escalation: 0.25 mg 0.5 mg 1.0 mg 1.7 mg 2.4 mg weekly Five-step titration over 16-20 weeks When combined in CagriSema, both peptides are dosed at 2.4 mg weekly, representing the maximum studied dose for each component

Up to approximately 2 months after the last instillation, significant improvement in OSSI and OSPI scores, pain VAS, voided volumes, frequency, and nocturia also were reported

Preclinical studies (in vitro and in vivo animal models) consistently demonstrate its robust regenerative and cytoprotective properties