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As a cofactor, cobalamins are essential for two cellular reactions: the mitochondrial methylmalonyl-CoA mutase conversion of methylmalonic acid (MMA) to succinate, which links lipid and carbohydrate metabolism, and the activation of methionine synthase, which is the rate-limiting step in the synthesis of methionine from homocysteine and 5-methyltetrahydrofolate

Standard treatment metformin, the oral contraceptive pill, spironolactone manages symptoms

Bioeng Translational Med

When assessing changes in HbA1c, there was a significant reduction in these levels seen after 32 weeks of treatment in comparison to baseline levels in the experimental groups receiving a combined treatment