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Under the impact of cytokines and mitogens present in atherosclerotic plaques, monocytes differentiate into macrophages, which engulf oxidized-LDL facilitated by ROS and p38MAPK signaling pathway and further differentiate into foam cells (,)

We think that the [neurons influence] on intervertebral disc degeneration is not only limited to the occurrence of pain, but also intervertebral disc degeneration itself, said Ximing Xu, professor in the Department of Orthopedic Surgery in Changzheng Hospital, and co-lead author of the study

Aging and type 2 inflammation The core of type 2 inflammation is the activation of Th2 and inherent lymphocyte2 (ILC2) pathways, and the phenotypes of type 2 inflammation usually interact and coordinate with each other in the skin and blood circulation (102)