antioxidant genes glutathione Glutathione! The antioxidant role of cellular

Acknowledgements This work was supported by grants from the National multidisciplinary collaborative diagnosis and treatment capacity building project for major diseases (TJZ202104), the Natural Science Foundation of China (82270643, 82070644, 82170621 and 82370645), the Science and Technology Major Program of Sichuan Province (2022ZDZX0019), the Sichuan Science and Technology Program (2024NSFSC0645), 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University (ZYJC18008, ZYGD22006)

In patients treated with escitalopram for 12 weeks, clinical remission was accompanied by serum reductions in neurotoxic KP metabolites, including 3-HK and QA, and a shift in metabolite ratios favouring a less excitotoxic profile (e.g., reduced QA/3-HK and increased KYNA/QA) [192]

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