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OOAC models have been employed to study various vascular diseases such as atherosclerosis, thrombosis, pulmonary arterial hypertension, and others as extensively reviewed by Amid Shakeri et al

In summary, the mechanism of 4-OH-E 1 s neuroprotective effect has two main elements: ( 1 ) 4-OH-E 1 protects neuronal survival by altering the function of p53 through promoting its translocation from nucleus to cytoplasm, thereby reducing its transcriptional activity and the expression of its downstream target genes (including GADD45)

However, repeat cycles of alcohol consumption and withdrawal cause severe BBB dysfunction and brain damage [33]

Mesenchymal stem cells (MSCs) release cytokines, growth factors, and anti-apoptotic proteins that diminish GC apoptosis, promote angiogenesis, and regulate inflammation