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21 that utilized a similar crossover design and demonstrated a significantly smaller reduction of mean 17-item Hamilton Depression Rating Scale (HAM-D) scores for a naltrexone-plus-ketamine compared to a placebo-plus-ketamine condition at day 1 postinfusion in individuals with treatment-resistant depression ( n = 12) with a similar effect size ( d = 0.7) to that found in this study ( d = 0.6)

2020;48(D1):D2658

Changes in dihydrolipoamide dehydrogenase expression and activity during postnatal development and aging in the rat brain

In cell and tissue models, Epithalon upregulates telomerase activity, maintains telomere length, and modulates aging-related gene expression (p16, p21) to delay senescence