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[7] Testicular Atrophy: When exogenous testosterone is present, the pituitary reduces LH output, and the testes shrink because they're not being stimulated to produce testosterone

Moreover, compromised intestinal barrier integrity and gut-derived microbial components such as LPS activate TLR/NF-B/NLRP3 pathways, which not only drive systemic inflammation but also modulate gut-derived tryptophan metabolism and serotonin synthesis, thereby coupling immune regulation with neuromodulatory functions

This raises to great concerns about the safety of nanomaterials, and puts forward higher requirements for the regulation of nanotoxicity

Age related changes in NAD+ metabolism oxidative stress and Sirt1 activity in wistar rats