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Such resistance to the Mn-SOD presence, however, might results from the differences in the kinetics of the competing reactions or because peroxide may not be released as a free intermediate 35

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Thus, TNBS promotes two independent mechanisms of injury, GSH depletion and ROS generation, both being required for the manifestation of mucosal injury as GSH limitation renders intestine susceptible to the TNBS-induced ROS overgeneration

For many reasons those series are unlikely to provide unbiased information about incidence or prevalence, because of the inevitable bias when legal liability may be involved, but they can act as broad indicators of risk, and even of the allergenic potential of particular substances (Drever, 1995)