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Here, we show that impaired OGDHc activity (via ABHD11 inhibition) in human CD8 + lymphocytes has distinct effects from those observed in cancer cells, with the perturbed TCA cycle driving synthesis of unsaturated fatty acids, rather than the accumulation of 2-HG that inhibits 2-OGDDs

Conflict of interest The authors declare that they have no competing financial interests or personal relationships that could have appeared to influence the work reported in this paper

In neurons, lactate is converted into pyruvate by lactate dehydrogenase 1, which then enters the TCA cycle and undergoes oxidative phosphorylation, resulting in the production of significant amounts of ATP to meet the energy demands of normal physiological activities

GSTs) has been studied in detail