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The PI3K signaling pathway is dysregulated in many tumors, and analyses have shown that PIK3CA is an oncogene that also contributes to tumor progression partially via metabolic reprogramming 188

This is in line with the results of previous studies which have also shown that analysis of VOCs in exhaled breath can be compatible with established strategies 72,73,74

Conversely, ferroptosis inhibitors, such as Lip-1, Fer-1, and DFO, have been shown to improve disease symptoms and extend the diminution of the colon length in dextran sulfate sodium (DSS)-induced colitis in mice, indicating that suppression of ferroptosis has a positive effect on IBD (140142)