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Abstract High-throughput phenotype-based screening of large libraries of novel compounds without known targets can identify small molecules that elicit a desired cellular response, but additional approaches are required to find and characterize their targets and mechanisms of action

Notably, in vivo model is complex, in which increases in the abundance of colitogenic bacteria Akkermansia and Bacteroides in the gut of IL10 / mice have been reported in parallel with the administration of PTEN inhibitors

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Vial G, Detaille D, Guigas B (2019) Role of mitochondria in the mechanism(s) of action of metformin