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NNMT (nicotinamide N-methyltransferase) is the enzyme 5-Amino-1MQ inhibits, and tissue expression varies significantly across organs: adipose tissue shows 812 higher NNMT activity than skeletal muscle, which is why subcutaneous injection near adipose depots produces localised effects rodent models couldn't predict

While both medications can lead to significant weight loss, these are different drugs with different mechanisms of action

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Importantly, formulation efforts emphasize stability under physiological conditions and resistance to fibril formationa limitation of earlier analogues such as pramlintide (Kruse et al