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Other cutaneous findings, such as NAs or JXGs have not been described, and systemic complications that are often associated with NF1 appear to be less frequent in MLNF.30 MLNF is usually asymptomatic but it can cause itching,31 or pain resulting from nerve root compression or malignant transformation.32,33 It is not uncommon for MLNF to be confused with other lesions such as nevus spilus, pigmentary mosaicism, or, very occasionally, segmental lentiginous pigmentation.34 These pigmentation disorders are very difficult to distinguish clinically from MLNF, and differentiation can only be achieved by molecular analysis of the tissue

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Phase II study of belzutifan (MK-6482), an oral hypoxia-inducible factor 2 (HIF-2) inhibitor, plus cabozantinib for treatment of advanced clear cell renal cell carcinoma (ccRCC)