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Experimental methods Animals Domestic short haired cats (all neutered) were housed at the Pet Health and Nutrition Center (PHNC), Lewisburg, OH, USA, and all procedures were approved by the WALTHAM Animal Welfare and Ethical Review Body and the PHNC Institutional Animal Care and Use Committee

These variations activate the nonenzymatic Maillard reaction, leading to the formation of glycation products and AGEs 5,19

Investig Clin Urol 58(Suppl 2):S90-S98

This shortage further manifested as downregulation of beta cell identity genes and a tonic increase in endoplasmic reticulum stress markers, which resulted in diminished insulin secretion both in vitro and in vivo