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The GSH system is linked with regulating pheomelanin formation

The Aldara cream contains an active agent called imiquimod (a Toll like receptor-7 agonist) and this cream can be used topically

These findings underscore the importance of NADPH in dealing with oxidative stress especially at times when most or all of the rods have degenerated, thereby exacerbating photo-oxidation due to increase of inflow of oxygen