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She worked as a planner in state and local government, beginning her career as the chief urban planner for Chicago area transportation studies, and, at the time of her retirement in 1983, she was a planning analyst for the Pennsylvania state planning and development office in Harrisburg

Thus, unraveling the molecular mechanisms of the TDP-43 pathology seems central to the ALS therapeutics, hence, we comprehensively review the current understanding of the TDP-43's pathology in ALS

There are varieties of studies that confirm this conclusion