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These mRNA packages are not like a viral vector that would be used for gene therapy, so they should not cause an immune response to these gene therapies

Additionally, autophagy inhibition reduced the inhibitory effects of Nampt silencing on ECM degradation in SUI fibroblasts

Raghunandan M, Yeo JE, Walter R, Saito K, Harvey AJ, Ittershagen S, Lee E, Yang J, Hoatlin ME, Bielinsky AK, Hendrickson EA, Schrer O, Sobeck A (2020) Functional cross talk between the Fanconi anemia and ATRX/DAXX histone chaperone pathways promotes replication fork recovery

However, despite their promising results, the associated side effects may render them less ideal