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doi: 10.1104/pp.114.4.1443 17 Gall.BelaK.HajmalA.FaragN.HorvthE.HorvthM.et al

At equimolar doses, this novel compound, GIC-1001 (trimebutine 3-thiocarbamoylbenzene-sulphonate), shows rapid onset of action (2 h) and more effectively mitigates nociceptive responses to colorectal distension, providing pain relief during colonoscopy (Table 4)