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SKU: 35159773068
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Besarab A, Zeig SN, Martin ER, et al

10.1038/35055553 Nature 71 NualartF

First, because Munc13-4 is mainly expressed in immune cells, ENDO-mediated inhibition of eTLRs and inflammation is more targeted than, for example, CQ derivatives

42 Topiramate is thought to act on the prefrontal cortex 18 and to exert its effects on the dopaminergic pathways from the ventral tegmental area to the nucleus accumbens, by enhancing GABAergic neurotransmission and antagonizing glutamatergic transmission, thereby leading to a decrease in dopamine in the nucleus accumbens