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In addition, other irritants including alcohol, radiation, and drug abuse are important triggers for intestinal barrier damage

The resulting ordered multivalent network enables simultaneous engagement of multiple POI and E3 ligase copies, promoting sustained, dose-dependent degradation and improved tumor retention

In this context, Hcy serves as a substrate for methionyl-tRNA synthetase (MARS), which catalyzes its conversion into homocysteine thiolactone (HTL), a highly reactive metabolite with enhanced cytotoxicity[14]