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Clinical research has found that older adults with T2DM are frequently associated with cardio-renal challenges and are more likely to have the risk of hypoglycemia in their frail body as well as merge multiple complications and comorbidities which seriously affect the quality of life and lifespan of the elderly ( FIGURE 1 2.1 The aging process and declining pancreatic function in elderly individuals As the metabolic capacity of the elderly declines, multiple metabolic disturbances combined with vascular aging contribute to the increasing prevalence of vascular complications in diabetes year by year

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In Western populations, alcohol appears less synergistic with HBV, while HCV infection and alcohol are more prominent drivers of HCC, whereas synergy with HBV has been observed in African contexts