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Riboflavin, Vitamin B6 & B12 contribute to normal red blood cells formation

While emerging evidence, including preclinical studies, early-phase trials, and limited clinical series, suggests that KD may help overcome treatment resistance by suppressing the PI3K/Akt/mTOR pathway, reducing insulin-like growth factor-1 (IGF-1) signaling, and enhancing cancer cell susceptibility to chemotherapy and targeted therapies, robust data from large, randomized controlled trials (RCTs) remain sparse

Pharmacokinetics, dose-response, and safety at these regimens havent been characterized in major peer-reviewed clinical trials

In the human study M1 was also observed, contributing 7.8% of total circulating radioactivity