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Because GHK-Cus value comes from sustained, systemic support rather than a one-time concentrated dose, the format thats easiest to use consistently without needles, mixing, or refrigeration is generally the more effective choice in practice

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In a randomized trial involving SLE patients, significant reduction in NET complexes was observed in individuals with the STAT4 risk allele who received Tofacitinib treatment, while no impact was observed in STAT4 risk allele-negative patients or those in the placebo group (134)